Cancer has an intricate Pathophysiology. Pathophysiology generally includes cause of the disease, diagnosis, how the disease develops (pathogenesis), mechanism and natural course of the disease. Pathology of cancers has experienced a mega change after development of technologies likeimmunohistochemistry, flow cytometer, and molecular biologic approaches to cancer diagnosis. Cancer defines a group of more than 150 disease processes characterized by uncontrolled growth and spread of cells. Cancer is not a singular, specific disease but a group of variable tissue responses that result in uncontrolled cell growth.This uncontrolled growth allows the cancer cells to annex adjacent structures and then destroy surrounding tissues and organs.The primary sites of cancer metastasis are the bone, the lymph nodes, the liver, the lungs, and the brain.