Genetic Changes and Cancer
Mutations are not only a hallmark of Cancer but may be central to how cancer Evolve. Human Cancer has equal Contribution both from Genetic and Epigenetic Changes. Genomic Alterations in Cancer vary from single nucleotide mutations to gross Chromosomal aneuploidy. The epigenetic factors involved in regulation of gene expression and genomic stability is DNA methylation. It is biologically necessary for the maintenance of many cellular functions.
- Genetic Instability in Cancer